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KMID : 1098420150230040298
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Korean Journal of Medicinal Crop Science
2015 Volume.23 No. 4 p.298 ~ p.304
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Effect of Dendrobium loddigesii Rolfe Methanol Extract on Melanogenesis in α-MSH Stimulated B16F10 Cells
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Jung Ho-Kyung
Jang Ji-Hun
Sim Mi-Ok
Lee Ki-Ho
Yeo Jun-Hwan
Kang Byoung-Man
Cho Jung-Hee
Bean Chul-Gu
Kim Seong-Cheol
Jung Won-Seok
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Abstract
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Dendrobium loddigesii (DL) is a valuable and versatile herbal medicine with the anecdotal claims of anti-oxidant and anti-inflammation. In the present study, we investigated the whitening effects of DL under various conditions with B16F10 melanoma cells. The DL extract inhibited melanin contents and tyrosinase activity in a dose-dependent manner, compared with untreated group. Treatment of the DL extract effectively suppressed the α-MSH-stimulated melanin formation, tyrosinase activity and dendrite outgrowth. Moreover, the α-MSH-induced mRNA expressions of tyrosinase-related protein-1 (TRP-1), tyrosinase-related protein-2 (TRP-2), microphthalmia-associated transcription factor (MITF) and protein expression of tyrosinase were significantly attenuated by DL treatment. These results indicate that DL may be a great cosmeceutical ingredient for its whitening effects.
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KEYWORD
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Dendrobium loddigesii, Whitening, Melanin, Tyrosinase
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